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Designing a Rational Supplement Protocol In order to understand what a rational supplement protocol looks like, Huberman says that individuals should take a step back and ask themselves, What are different supplements designed to do? Foundational Supplements and Single Ingredient Formulations Among the myriad of supplements available, Huberman recommends that individuals first hone in on foundational supplements, which he says help ensure were getting all we need for a basic level of mental health, physical health, and performance